Vincristine sulfate

Product Introduction: Vincristine sulfate Powder

Overview

Vincristine sulfate is a chemotherapy medication belonging to a class of drugs known as vinca alkaloids. Here are the key points about Vincristine sulfate:

1.Anti-cancer Properties: Vincristine sulfate is primarily used in the treatment of various cancers, including acute lymphocytic leukemia (ALL), Hodgkin's disease, non-Hodgkin's lymphomas, neuroblastoma, rhabdomyosarcoma, and Wilms' tumor among others. It works by disrupting the formation of the mitotic spindle during cell division, thereby inhibiting cell proliferation.

2.Mechanism of Action: Vincristine sulfate binds to tubulin, a protein component of microtubules essential for cell division. By binding to tubulin, it prevents the formation of the mitotic spindle, which is necessary for segregating chromosomes during mitosis. This disruption ultimately leads to cell cycle arrest and cell death (apoptosis) in rapidly dividing cancer cells.

3.Administration: It is administered intravenously (IV) due to poor oral bioavailability. It is typically given slowly to minimize potential side effects associated with rapid infusion.

4.Dosage and Schedule: The dosage of Vincristine sulfate and the treatment schedule depend on the type of cancer being treated, the patient's overall health, and other factors determined by the treating oncologist.

5.Side Effects: Common side effects of Vincristine sulfate include peripheral neuropathy (tingling, numbness, or pain in the hands and feet), constipation, hair loss, jaw pain (due to muscle spasms), and gastrointestinal issues. Severe allergic reactions and neurotoxicity can also occur but are less common.

6.Special Considerations: Vincristine sulfate is typically part of a combination chemotherapy regimen rather than used alone. It is often combined with other chemotherapy drugs to maximize its effectiveness against different types of cancer.

7.Monitoring: Patients receiving Vincristine sulfate require careful monitoring for both efficacy and potential side effects throughout their treatment course. Dose adjustments may be necessary based on individual response and tolerability.

Overall, Vincristine sulfate plays a critical role in the treatment of several types of cancers by disrupting the cell division process in cancer cells. Its use is guided by oncologists who consider its potential benefits and risks for each patient's specific condition.

Functional Properties

Here are its functional properties:

1.Microtubule Inhibition: Vincristine sulfate binds to tubulin, a protein that forms microtubules, essential components of the cytoskeleton involved in cell division (mitosis). By binding to tubulin, vincristine interferes with microtubule assembly dynamics, thereby disrupting the formation of the mitotic spindle. This disruption prevents proper segregation of chromosomes during cell division, leading to mitotic arrest and ultimately cell death through apoptosis.

2.Cell Cycle Specificity: Vincristine sulfate primarily affects cells in the M-phase (mitosis) of the cell cycle.

3.Selective Toxicity: While vincristine sulfate affects rapidly dividing cells, it tends to spare non-dividing cells to some extent. This selective toxicity is a key characteristic of many chemotherapy drugs, aiming to minimize damage to healthy tissues while targeting cancer cells.

4.Treatment of Various Cancers: Vincristine sulfate is used in the treatment of a wide range of cancers, including acute lymphocytic leukemia (ALL), Hodgkin's disease, non-Hodgkin's lymphomas, neuroblastoma, rhabdomyosarcoma, and Wilms' tumor. Its effectiveness varies depending on the type and stage of cancer being treated.

5.Administration and Pharmacokinetics: It is administered intravenously (IV) due to its poor oral bioavailability. Vincristine sulfate is typically given slowly to reduce the risk of infusion-related reactions and toxicity.

6.Combination Therapy: Vincristine sulfate is often used in combination with other chemotherapy agents to achieve synergistic effects and improve treatment outcomes. These combinations are tailored based on the specific cancer type and individual patient characteristics.

7.Side Effects: Common side effects of vincristine sulfate include peripheral neuropathy (tingling, numbness, or pain in the hands and feet), constipation, hair loss, jaw pain, and gastrointestinal issues. Neurotoxicity is a significant concern, particularly with prolonged use or higher doses.

8.Monitoring and Management: Patients receiving vincristine sulfate require close monitoring for both therapeutic response and adverse effects. Dose adjustments may be necessary based on individual tolerance and the development of side effects.

Understanding these functional properties underscores the mechanism of action and clinical use of vincristine sulfate in oncology. Its role in cancer treatment highlights its importance as part of comprehensive chemotherapy regimens aimed at targeting and controlling malignancies.

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Specifications

PACKING AND SHIPPING

< 1kg---Package: Alu-bag；

<10 KG/Al-Tin---Package: 2 pcs Alu-tin with box；

<25 KG--- Package: Drum (53*36*37cm)=0.07CBM N.G.:25KG, W.G.:28KG

Transportation can be selected based on the weight of the goods and customer needs, which can be TNT, FEDEX, DHL, UPS, EMS. For large orders, they will generally be delivered by air or sea freight.

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Our company takes creating high-quality and healthy products as our mission, ensuring product quality as our principle, and has passed ISO9001 quality management system certification, halal and Jewish certification. The company has been constantly striving and has been awarded the high-tech enterprise certificate for many consecutive years.

OUR FACTORY

Jiubaiyuan is a plant extract manufacturer with over 20 years of professional experience. For many years, we have been specializing in the research and production of Vincristine sulfate. The Vincristine sulfate produced using unique technology has excellent quality, reasonable price, and supports third-party professional institutions for testing. The application fields include beverage, food, cosmetics, dietary supplements, and other industries. Please contact us for more details!

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